181 research outputs found
Development of Continuous Voice Morphing Using Separated Vocal Tract Area Functions, Glottal Source Waves, and Prosodic Features
科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(C)2010-2012課題番号:2250014
Long-term survivor diagnosed with arrhythmogenic right ventricular cardiomyopathy/dysplasia
The subject was a 70 year-old man who survived for 31 years after being diagnosed with right
ventricular cardiomyopathy, having undergone right ventricular (RV) aneurysmectomy at the
age of 39. His arrhythmia and syncopal attacks were effectively abolished after the original
aneurysmectomy. Although he frequently suffered from right heart failure, hemodialysis improved
his status. However, the patient died due to worsening anasarca caused by RV low
output syndrome. Autopsy results indicated extensive replacement of the RV myocardium with
fibrous and fatty tissues. This case suggests that patients with arrhythmogenic RV cardiomyopathy,
but without left ventricular abnormalities and rapid ventricular arrhythmia, have
a relatively favorable prognosis, although RV abnormalities may be progressive
Development of holistic vs. featural processing in face recognition
According to a classic view developed by Carey and Diamond (1977), young children process faces in a piecemeal fashion before adult-like holistic processing starts to emerge
at the age of around 10 years. This is known as the
encoding switch hypothesis . Since then,a growing body of studies have challenged the theory. This article will provide a critical appraisal of this literature, followed by an analysis of some more recent developments.
We will conclude, quite contrary to the classical view, that holistic processing is not only present in early child development, but could even precede the development of part-based processing
Cell type–specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells
The zinc finger transcription factor, Bcl11b, is expressed in T cells and group 2 innate lymphoid cells (ILC2s) among hematopoietic cells. In early T-lineage cells, Bcl11b directly binds and represses the gene encoding the E protein antagonist, Id2, preventing pro-T cells from adopting innate-like fates. In contrast, ILC2s co-express both Bcl11b and Id2. To address this contradiction, we have directly compared Bcl11b action mechanisms in pro-T cells and ILC2s. We found that Bcl11b binding to regions across the genome shows distinct cell type–specific motif preferences. Bcl11b occupies functionally different sites in lineage-specific patterns and controls totally different sets of target genes in these cell types. In addition, Bcl11b bears cell type–specific post-translational modifications and organizes different cell type–specific protein complexes. However, both cell types use the same distal enhancer region to control timing of Bcl11b activation. Therefore, although pro-T cells and ILC2s both need Bcl11b for optimal development and function, Bcl11b works substantially differently in these two cell types
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